Proje Çıktıları

“İlk yılı itibariyle, MAESTRO'nun yoğun Ar-Ge faaliyetleri sonucunda çeşitli ara ürünler ve yan ürünler elde edilmeye başlamıştır. Mikrofabrikasyon, biyosensörler ve mikroakışkan teknolojiler üzerine odaklanan çalışma gruplarımız, başarılı bir şekilde ortak ürün geliştirme çalışmalarını yürütmektedir.

Bu heyecan verici gelişmelerin yanı sıra, MAESTRO platformu olarak, ortak ürünlerimizin tescil süreçlerine yönelik planlamalarımızı başlatmış bulunuyoruz. Güçlü bir AR-GE ekibi, ileri teknoloji çözümlerimiz ve etkileyici paydaş ağımızla, medikal sektörde öncü ve yenilikçi bir platform olma hedefimize her geçen gün bir adım daha yaklaşıyoruz.”

Makaleler

Betül Karakuzu, Müge Anıl İnevi, Ergün Alperay Tarım, Öykü Sarıgil, Meltem Güzelgülgen, Seren Keçili, Selin Çeşmeli, Sadık Koç, M. Semih Baslar, Ceyda Öksel Karakuş, Engin Özçivici, Hüseyin Cumhur Tekin, “Magnetic levitation-based miniaturized technologies for advanced diagnostics.", Emergent Materials, 2024.

https://link.springer.com/article/10.1007/s42247-024-00762-6

Betül Karakuzu, Hüseyin Cumhur Tekin, “Creatinine-on-a-chip: colorimetric ELISA-based serum creatinine detection in a microfluidic device.”, Analyst 2025, 150, 4395-4403.

https://pubs.rsc.org/en/content/articlelanding/2025/an/d5an00650c

Cemre Öksüz, Can Biçmen, Hüseyin Cumhur Tekin, "Dynamic fluidic manipulation in microfluidic chips with dead-end channels through spinning: the Spinochip technology for hematocrit measurement, white blood cell counting and plasma separation.", Lab Chip, 2025, 25, 1926-1937.

https://pubs.rsc.org/en/content/articlelanding/2025/lc/d4lc00979g

Erçil Toyran, Farzad Rokhsar Talabazar, Iakovos Tzanakis, Morteza Ghorbani, Ali Koşar, “Cavitating flow morphology determination in cavitation-on-a-chip devices based on local real-time pressure measurements.", Physics of Fluids 37 (2), 2025.

https://pubs.aip.org/aip/pof/article/37/2/022009/3333648/Cavitating-flow-morphology-determination-in

Seyedreza Tebyani, Erçil Toyran, Farzad Rokhsar Talabazar, Morteza Ghorbani, Ali Koşar, "Acoustic characterization of cavitating flows in a microfluidic venturi reactor.", Physics of Fluids 37 (8), 2025.

https://pubs.aip.org/aip/pof/article-abstract/37/8/082142/3360571/Acoustic-characterization-of-cavitating-flows-in-a?redirectedFrom=fulltext

Seren Keçili, Sümeyra Vural Kaymaz, Beyzanur Özogul, Hüseyin Cumhur Tekin, Meltem Elitaş, “Investigating influences of intravenous fluids on HUVEC and U937 monocyte cell lines using the magnetic levitation method.” Analyst. 2023 Nov 6;148(22):5588-5596.

https://pubmed.ncbi.nlm.nih.gov/37872817/

Öykü Doyran İnce, Hüseyin Cumhur Tekin, "MagSity platform: a hybrid magnetic levitation-based lensless holographic microscope platform for liquid density and viscosity measurements.”, Lab Chip, 2025, 10.1039/D5LC00144G.

https://pubs.rsc.org/en/content/articlelanding/2025/lc/d5lc00144g

Vildan Şanko, Hüseyin Cumhur Tekin, “Electrochemical sensors for rapid cardiovascular disease diagnostics.”, ACS Sensors 2025, 10, 6316–6346.

https://pubs.acs.org/doi/10.1021/acssensors.5c01921

Bildiriler

Ali Can Atik, Leman Dicle Balcı, Özlem Topçu, Akın Mert Yılmaz, Şahin Hanalioğlu, Hülya Karataş Kurşun, Hasan Uluşan, Mahmut Kamil Aslan, Haluk Külah, “Mems-Based Su-8 Neural Probes for Enhanced Neuromonitoring”, 25th International Conference On Spreading Depolarizations (iCSD 2024)

Ali Can Atik, Özlem Topçu, Akın Mert Yılmaz, Leman Dicle Balcı, Şahin Hanalioğlu, Hasan Uluşan, Mahmut Kamil Aslan, Haluk Külah, “A Mems-Based Thin Film Microelectrode Array for Monitoring of Traumatic Brain Injury”, 25th International Conference On Spreading Depolarizations (iCSD 2024)

Ayşen Gümüştaş, Hilal Torul, Uğur Tamer, Ender Yıldırım, “Development of an electrochemical biosensor for the determination of lactate dehydrogenase”, 33rd International Symposium on Pharmaceutical and Biomedical Analysis

Ayşen Gümüştaş, Hilal Torul, Kübra Özkan Hüküm, Uğur Tamer, Ender Yıldırım, "Conducting Polymer Based Amperometric Sensor for the Determination of Lactate Dehydrogenase", 35th Anniversary World Congress on Biosensors (Biosensors 2025)

Betül Karakuzu, Engin Özçivici, Hüseyin Cumhur Tekin, ” Measuring magnetic susceptibility and density of microparticles using a magnetic levitation platform”, ACS Spring 2024

Büşra Erimez, Hüseyin Cumhur Tekin, "Artificial Intelligence-Driven Wearable Device for Sleep Apnea Classification", 35th Anniversary World Congress on Biosensors (Biosensors 2025)

Elif Miray Arpacık, Recep Baş, İlhami Ünal, Cihat Taşaltın, “Akıllı Stent Geliştirilmesine Yönelik Anten Tasarımında Kapasitans Değişiminin İncelenmesi”/“Investigations of Capacitance Change In Antenna Design for Smart Stent Development”, Elektrik-Elektronik Ve Biyomedikal Mühendisliği Konferansı

Feyza Pirim, Akın Mert Yılmaz, Ali Can Atik, Haluk Külah, Mahmut Kamil Aslan, “Fabrication and Characterization of MEMS-Based Parylene Microchannels for Drug Delivery to Brain”, MicroTAS 2023

Fikrettin Şahin, Emre Cebeci, Büşra Yüksel, Cansın Deniz, Talar Gedik, Semih Yeter, "Kannabidiol (Cbd)’Ün Antikanser Etkisinin 2 Boyutlu Ve 3 Boyutlu Hücre Kültürlerinde Kıyaslanması"

Fikrettin Şahin, Emre Cebeci, Büşra Yüksel, Cansın Deniz, Talar Gedik, Semih Yeter, "Sodyum Boratlarin Antikanser Etkisinin 2 Boyutlu Ve 3 Boyutlu Kültür Sistemlerinde Kıyaslanması"

Hatice Ahsen Özcan, Seren Keçili, Hüseyin Cumhur Tekin, "Magnetic Levitation-Based Endothelial Cell Sorting", 2023 Medical Technologies Congress (TIPTEKNO 2023)

Hilal Döğer, Hüseyin Cumhur Tekin, "Lensless digital in-line holographic microscopy for the detection of microplastics", 4th BioMEMS and Microfluidic Technologies Workshop, jointly organized with the 6th Novel Fluidic Technologies Workshop

Hilal Torul, Ayşen Gümüştaş, Uğur Tamer, Ender Yıldırım, “Enhanced Electrochemical Biosensor for Sensitive NADH Detection”, 35th Anniversary World Congress on Biosensors (Biosensors 2025)

Hüseyin Cumhur Tekin, “Magnetic Levitation for 3D Cell Culture in Miniaturized Platform”, International Workshop on Emerging Organ-on-Chip Technologies

Hüseyin Cumhur Tekin, "Miniaturized Magnetic Levitation-Based Strategies for Advanced Biomarker Detection", 17th Nanoscience & Nanotechnology Conference (NanoTR-17)

İlhan Can Özen, Nazire Pınar Acar Özen, Meryem Aslı Tuncer, “Pre-diagnostic Health Trajectories in Multiple Sclerosis: A Retrospective Claims-Based Study”, 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2025)

Mehmet Oğulcan Güngör, Miray Sanem Sarı, Parya Teymoory, Jerome Charmet, Ender Yıldırım, “A Graphite-Based Approach to Elevate Replication Quality in Rapid Injection Molding of Microfluidic Devices With Recycled PMMA”, 4th Additive Manufacturing Conference (AMC 2024)

Mehmet Oğulcan Güngör, Meltem Okan, Vildan Şanko, Hüseyin Cumhur Tekin, Haluk Külah, Ender Yıldırım, "Microfluidics Made Simple: A Low-Cost, High-Performance Biosensor Platform Using SPEs, MIPs, and Rapid Injection Molding", 35th Anniversary World Congress on Biosensors (Biosensors 2025)

Merve Gizer, Selin Önen, Özgür Doğuş Erol, Fatima Aerts Kaya, Petek Korkusuz, "Cannabinoid 2 Receptor Agonism Induces proliferation and Commitment to Spermatogonial Stem Cell Differentiation of Human Induced pluripotent Stem Cells", the ISSCR 2024 Annual Meeting (ISSCR24)

Petek Korkusuz, Selin Önen, Merve Gizer, “In vitro Spermatogenesis Platforms”, 2023 ISOMRM & BCRS

Sadık Koç, Furkan Bora Cehiz, Büşra Erimez, Hüseyin Cumhur Tekin, "Automated Cell Sorting via Image Analysis in a Magnetic Levitation System", 4th BioMEMS and Microfluidic Technologies Workshop, jointly organized with the 6th Novel Fluidic Technologies Workshop

Sadık Koç, Furkan Bora Cehiz, Büşra Erimez, Hüseyin Cumhur Tekin, "Real-Time Image-Based Active Cell Sorting in a Magnetic Levitation Platform", 35th Anniversary World Congress on Biosensors (Biosensors 2025)

Seçkin Eroğlu, Ayda Önsoy, Can Önol, Çağrı Öztürk, Barbaros Çetin, Ender Yıldırım, “Modeling of Microfluidic MEMS-based Capacitive Pressure Measurement”, 15th International Conference on Computational Heat & Mass Transfer (ICCHMT’25)

Seren Keçili, Müge Anıl İnevi, Öykü Sarıgil, Engin Özçivici, Hüseyin Cumhur Tekin, "Magnetic Levitational Technologies for Tissue Engineering Applications", 5th Novel Fluidic Technologies Workshop with an Emphasis on Tissue Engineering

Seren Keçili, Engin Özçivici, Hüseyin Cumhur Tekin, "Finite Element Modeling of Magnetic Levitation-Based 3D Cellular Patterns", 27th National Biomedical Science and Technology Symposium

Seren Keçili, Hüseyin Cumhur Tekin, “Magnetic levitation-based formation and dynamic rotation of 3D clusters of microspheres and HUVEC cells in a microfluidic chip”, International Workshop on Emerging Organ-on-Chip Technologies

Seren Keçili, Hüseyin Cumhur Tekin, “Magnetic levitation-based formation and dynamic rotation of 3D clusters of microspheres and HUVEC cells in a microfluidic chip”, EUROoCS Annual Meeting

Seren Keçili, Hatice Ahsen Özcan, Zeliha Soran Erdem, Hüseyin Cumhur Tekin, "Magnetic Levitation-assisted Fluorescent Detection of Proteins Using Superparamagnetic Iron Oxide Nanoparticles", 4th BioMEMS and Microfluidic Technologies Workshop, jointly organized with the 6th Novel Fluidic Technologies Workshop

Seren Keçili, Hatice Ahsen Özcan, Zeliha Soran Erdem, Hüseyin Cumhur Tekin, "Fluorescent-based Protein Detection with Superparamagnetic Iron Oxide Nanoparticles Using Magnetic Levitation Technology", 35th Anniversary World Congress on Biosensors (Biosensors 2025)

Şeyda Keleş, Betül Karakuzu, Hüseyin Cumhur Hüseyin Cumhur Tekin, "3D Printing-assisted fabrication of microfluidic penumatic valves", 2023 Medical Technologies Congress (TIPTEKNO 2023)

Şeyda Keleş, Ergün Alperay Tarım, Hatice Ahsen Özcan, Hüseyin Cumhur Tekin, “Rapid Prototyping of Microfluidic Channels Using 3D-Printer for Density Based Analysis of Microparticles in a Magnetic Levitation Platform”, 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2024)

Şeyda Keleş, Hüseyin Cumhur Tekin, “Magnetic Levitation-Based Cytometry in a Microfluidic Chip via Deep Learning-Assisted Analysis”, 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2024)

Kitap Bölümleri

https://link.springer.com/article/10.1007/s42247-024-00762-6

Cemre Öksüz, Ergün Alperay Tarım, H. Ahsen Özcan, Sadık Koç, Hüseyin Cumhur Tekin, "Sample preparation using microfluidic technologies for non-invasive tests." Comprehensive Sampling and Sample Preparation (Second Edition), Volume 3, 405-426, 2025 Elsevier eBook.

https://www.researchgate.net/publication/382630872_Sample_preparation_using_microfluidic_technologies_for_non-invasive_tests

İlhan Can Özen, Berna Tuncay Alpanda, “Strangers in a New Land: Evaluating the Diagnostic Effectiveness of the Turkish Health System in the Context of Syrian Refugees” Transforming Health in Turkey: An Evaluation of Two Decades of Reform (Routledge), 2025.

https://www.taylorfrancis.com/chapters/edit/10.4324/9781003539896-5/strangers-new-land-evaluating-diagnostic-effectiveness-turkish-health-system-context-syrian-refugees-i%CC%87lhan-%C3%B6zen-berna-tuncay-alpanda

Selin Önen, Merve Gizer, İmran Özge Çolak, Petek Korkusuz, “Bioengineering Approaches for Male Infertility: From Microenvironmental Regeneration to in vitro Fertilization.” Advances in Experimental Medicine and Biology, Springer, Cham., 2025.

https://link.springer.com/chapter/10.1007/5584_2024_844

Patentler

Erçil Toyran, Farzad Rokhsar Talabazar, Ünal Akar, Özlem Kutlu, Sibel Çetinel, Morteza Ghorbani, Ali Koşar, “Synchronization of local pressure and acoustic data for detecting and characterizing cavitating flow patterns in microfluidic devices without any flow visualization”.

Patent Başvuruları

Ender Yıldırım, Uğur Tamer, Hilal Torul, Ayşen Gümüştaş, Kübra Özkan Hüküm, "Elektrokimyasal Sensör ile Amperometrik Laktat Dehidrogenaz Tayini", 2024/016998.

Hüseyin Cumhur Tekin, Öykü Doyran İnce, “Sıvıların Viskozite ve Öz Kütle Ölçümü İçin Lenssiz Holografik Mikroskop Entegre Manyetik Levitasyon Platformu”, 2024/018026.

İsmail Bütün, Ezgi Kestek, Ünal Akar, Morteza Ghorbani, Ali Koşar, “Cavitation detection and intensity mapping by using surface acoustic wave sensors”

Buluş Bildirimleri

Haluk Külah, Ali Can Atik, Özlem Topçu, Şahin Hanalioğlu, “MEMS-Tabanlı Mikrokanal-Entegre Hibrit Otonom Nöral Monitorleme Cı̇hazı”

Haluk Külah, Ali Can Atik, Özlem Topçu, Şahin Hanalioğlu, Hülya Karataş Kurşun, “MEMS-Tabanlı Çoklu Modaliteye Sahip Entegre Nöral Prob”

Başak Şentürk, Kevser Buse Karadeniz, Eylül Ece İşlek Camadan, Ahmet Can Timuçin, Tanıl Kocagöz, Özge Can, “Kardiyak Troponin İ’ye Yüksek Afinite ile Bağlanan Bilgisayarlı Modelleme ile Tasarlanmış Peptitler”

Başak Şentürk, Kevser Buse Karadeniz, Eylül Ece İşlek Camadan, Ahmet Can Timuçin, Tanıl Kocagöz, Özge Can, “Yağ Asidi Bağlayıcı Protein-3’e (FABP3) Yüksek Afinite ile Bağlanan Bilgisayarlı Modelleme ile Tasarlanmış Peptitler”

Başak Şentürk, Kevser Buse Karadeniz, Eylül Ece İşlek Camadan, Ahmet Can Timuçin, Tanıl Kocagöz, Özge Can, “Kopeptin’e Yüksek Afinite ile Bağlanan Bilgisayarlı Modelleme ile Tasarlanmış Peptitler”

Başak Şentürk, Kevser Buse Karadeniz, Eylül Ece İşlek Camadan, Ahmet Can Timuçin, Tanıl Kocagöz, Özge Can, “Miyoglobin’e Yüksek Afinite ile Bağlanan Bilgisayarlı Modelleme ile Tasarlanmış Peptitler”

Ender Yıldırım, Haluk Külah, Çağrı Öztürk, “Tamamen Temas Modunda Çalışan Kapasitif Basınç Sensörü”

İlke Gürol, Zeynep Münteha Şahin, Günseli Güney, “Kandan kırmızı kan hücrelerini etkin bir şekilde ayıran yeni jel formülasyonları”

Petek Korkusuz, Haluk Külah, Selin Önen Korkmaz, Merve Gizer Bayhan, Meltem Okan Aydın, Zeynep Çağlayan Arslan, Ali Can Atik, Ege Tongün, İmran Özge Çolak, "Hücresel tedavi ajanı destekli elektrokimyasal testosteron sensörü entegreli çip-üstü spermatogenez platformu"

Tamamlanan Bilimsel Tezler

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Ürünler

Ataletsel Mikroakışkan Karıştırıcı Cihazı
Çip Üstü Kavitasyon Cihazı
Mikroakışkan Valf Yapıları

Ana Ürünler

Minyatür Şırınga Pompası
Hücrelerin Özkütle Analizinin Yapılabileceği ve İlaca Verdikleri Tepkilerin Gözlemleneceği Manyetik Levitasyon Düzeneği
Sıvıların Özkütle ve Vizkozitelerini Ölçmeyi Sağlayan Merceksiz Holografik Mikroskop Entegreli Manyetik Levitasyon Düzeneği
Selenoid Valflerin Kontrolünü Sağlayacak Elektronik Kontrol Ünitesi ve Yazılımı